Remove a Domain User Profile from Windows 10

To delete a user profile in Windows 10, do the following.

Press Win + R hotkeys on the keyboard. The Run dialog will appear on the screen. Type the following into the text box and press Enter:
SystemPropertiesAdvanced

Advanced System Properties will open. There, click on the Settings button in the User Profiles section.

In the User Profiles window, select the profile of the user account and click the Delete button.

The next time the user signs in, his or her profile will be re-created automatically, with all the default options and settings.

You might also be interested in learning how to delete a user profile manually. This procedure involves File Explorer and the Registry editor app.

Delete a user profile in Windows 10 manually

Go to the folder C:\Users and look for the user name which you want to delete. The appropriate folder contains everything related to the user profile, so you just need to delete this folder.

Go to the following Registry key.
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList
See how to go to a Registry key with one click.

On the left, go through the subkeys. For each subkey, look for the value data of the ProfileImagePath string value. Once you find the one which points to the deleted user profile, remove it. See the following screenshot:

That's it! You just deleted the user profile for the account. It will be re-created using defaults the next time the user signs in.